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Cyp4s3 Cytochrome P450 4s3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32444, updated on 18-Sep-2024

Summary

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Official Symbol
Cyp4s3provided by FlyBase
Official Full Name
Cytochrome P450 4s3provided by FlyBase
Primary source
FLYBASE:FBgn0030615
Locus tag
Dmel_CG9081
See related
AllianceGenome:FB:FBgn0030615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4s3; CG9081; Dmel\CG9081; RE63964
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head and embryonic/larval fat body. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
13A12-13A12; 1-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15113302..15116542, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15007335..15010575, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dihydrolipoamide branched chain transacylase E2 Neighboring gene Rab3 GDP-GTP exchange factor Neighboring gene uncharacterized protein Neighboring gene drop dead Neighboring gene Ribosomal protein L37-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
  2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
  3. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
  4. Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila. Zheng Y, et al. BMC Genomics, 2011 Dec 6. PMID 22145623, Free PMC Article
  5. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Bouché V, et al. Autophagy, 2016. PMID 26761346, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4s3
Names
CG9081-PA
Cyp4s3-PA
cytochrome P450
NP_573003.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15113302..15116542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132775.3 → NP_573003.2  cytochrome P450 4s3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573003.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VXY0
    UniProtKB/TrEMBL
    I1WYI3, Q8SYF6
    Related
    FBpp0073845
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 469
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYF6 Q8SYF6
Q9VXY0.1 Q9VXY0

Gene LinkOut

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