lmbrd1 LMBR1 domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lmbrd1provided by ZNC
Official Full Name: LMBR1 domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-36
See related: Ensembl:ENSDARG00000104223 AllianceGenome:ZFIN:ZDB-GENE-041212-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LMBD1; fc08a03; wu:fc08a03; zgc:103471
Summary: Predicted to enable cobalamin binding activity. Predicted to be involved in protein localization to lysosome. Predicted to act upstream of or within insulin receptor internalization. Predicted to be located in clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; and plasma membrane. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblF. Orthologous to human LMBRD1 (LMBR1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (38621517..38792061, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (38495627..38666171, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cobalamin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insulin receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to lysosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysosomal cobalamin transport escort protein LMBD1

Names: LMBR1 domain-containing protein 1; probable lysosomal cobalamin transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.