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AMPdeam AMP deaminase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32352, updated on 18-Sep-2024

Summary

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Official Symbol
AMPdeamprovided by FlyBase
Official Full Name
AMP deaminaseprovided by FlyBase
Primary source
FLYBASE:FBgn0052626
Locus tag
Dmel_CG32626
See related
AllianceGenome:FB:FBgn0052626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AMP deam; CG11058; CG11065; CG15762; CG32626; Dmel\CG32626
Summary
Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including dorsal closure embryo; embryonic epidermis; embryonic/larval garland cell; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See AMPdeam in Genome Data Viewer
Location:
12C6-12C7; 1-46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13830741..13845866, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13724774..13739899, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 93kD-1 Neighboring gene Ajuba LIM protein Neighboring gene maternal gene required for meiosis Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44655

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors. Leung HT, et al. Neuron, 2008 Jun 26. PMID 18579079, Free PMC Article
  2. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
  3. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551
  4. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353
  5. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AMP deaminase
Names
AMPdeam-PC
AMPdeam-PE
AMPdeam-PF
AMPdeam-PG
AMPdeam-PH
AMPdeam-PI
AMPdeam-PJ
AMPdeam-PK
AMPdeam-PL
CG32626-PC
CG32626-PE
CG32626-PF
CG32626-PG
CG32626-PH
CG32626-PI
CG32626-PJ
CG32626-PK
CG32626-PL
NP_001188588.1
NP_001245659.1
NP_001245660.1
NP_001285233.1
NP_001285234.1
NP_572931.1
NP_727739.3
NP_727740.2
NP_727741.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13830741..13845866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258730.2 → NP_001245659.1  AMP deaminase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245659.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDW2
    Conserved Domains (1) summary
    cl00281
    Location:148 → 183
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. NM_167384.3 → NP_727739.3  AMP deaminase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727739.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY76
    Conserved Domains (2) summary
    PLN03055
    Location:221 → 757
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:257 → 753
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  3. NM_001298304.1 → NP_001285233.1  AMP deaminase, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285233.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JEY5
    Conserved Domains (2) summary
    PLN03055
    Location:248 → 784
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:284 → 780
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  4. NM_167385.4 → NP_727740.2  AMP deaminase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727740.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4U3, Q76NQ9
    Conserved Domains (2) summary
    PLN03055
    Location:99 → 635
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:135 → 631
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  5. NM_167386.2 → NP_727741.3  AMP deaminase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727741.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q76NR0
    Conserved Domains (2) summary
    PLN03055
    Location:224 → 760
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:260 → 756
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  6. NM_001258731.2 → NP_001245660.1  AMP deaminase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245660.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQK3, M9NGE0
    Conserved Domains (2) summary
    PLN03055
    Location:148 → 763
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:263 → 759
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  7. NM_001298305.1 → NP_001285234.1  AMP deaminase, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFA0
    Conserved Domains (2) summary
    PLN03055
    Location:236 → 772
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:272 → 768
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  8. NM_001201659.1 → NP_001188588.1  AMP deaminase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS55
    Conserved Domains (2) summary
    PLN03055
    Location:239 → 775
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:275 → 771
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

  9. NM_132703.3 → NP_572931.1  AMP deaminase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961Q7
    Related
    FBpp0073664
    Conserved Domains (2) summary
    PLN03055
    Location:78 → 693
    PLN03055; AMP deaminase; Provisional
    cd01319
    Location:193 → 689
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0IQK3 D0IQK3
M9MS55 M9MS55
M9NDW2 M9NDW2
Q76NQ9 Q76NQ9
Q76NR0 Q76NR0
Q961Q7 Q961Q7
Q9VY76 Q9VY76
X2JEY5 X2JEY5
X2JFA0 X2JFA0

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