U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ip6k2a inositol hexakisphosphate kinase 2a [ Danio rerio (zebrafish) ]

Gene ID: 322041, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ip6k2aprovided by ZNC
Official Full Name
inositol hexakisphosphate kinase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-760
See related
Ensembl:ENSDARG00000008310 AllianceGenome:ZFIN:ZDB-GENE-030131-760
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ihpk2; ip6k2; cb1087; wu:fb47g07; wu:fi24d03
Summary
Predicted to enable inositol hexakisphosphate kinase activity. Acts upstream of or within positive regulation of smoothened signaling pathway and signal transduction downstream of smoothened. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; immature eye; nervous system; pronephric duct; and segmental plate. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ip6k2a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (42409079..42418165, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (42411713..42420629, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 1b Neighboring gene ER membrane protein complex subunit 3 Neighboring gene macrophage stimulating 1 receptor a Neighboring gene CaM kinase-like vesicle-associated a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. Sarmah B, et al. Proc Natl Acad Sci U S A, 2010 Nov 16. PMID 20980661, Free PMC Article
  2. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IP6K2 is a positive regulator of Hh signaling.
    Title: Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inositol hexakisphosphate kinase 2a
Names
inositol hexaphosphate kinase 2
inositol hexaphosphate kinase 2a
NP_958878.1
XP_021332456.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201470.1 → NP_958878.1  inositol hexakisphosphate kinase 2a

    See identical proteins and their annotated locations for NP_958878.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059642
    UniProtKB/TrEMBL
    A0A8M1PCI0, Q6PBN6
    Related
    ENSDARP00000011601.6, ENSDART00000002501.7
    Conserved Domains (1) summary
    pfam03770
    Location:201 → 455
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    42409079..42418165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476781.1 → XP_021332456.1  inositol hexakisphosphate kinase 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QA58
    Conserved Domains (1) summary
    pfam03770
    Location:82 → 336
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous