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Pkcdelta Protein kinase C delta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32191, updated on 18-Sep-2024

Summary

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Official Symbol
Pkcdeltaprovided by FlyBase
Official Full Name
Protein kinase C deltaprovided by FlyBase
Primary source
FLYBASE:FBgn0287828
Locus tag
Dmel_CG42349
See related
AllianceGenome:FB:FBgn0287828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10524; CG11245; CG42349; delta PKC; Dmel\CG42349; mfd; PKCd; PKCdelta
Old locus tag
Dmel_CG10524; Dmel_CG11245
Summary
Predicted to enable ATP binding activity and protein kinase C activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Is expressed in adult brain. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
11A10-11A11; 1-38 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12432224..12453650)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12326257..12347683)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32652 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45615 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Rosdahl JA, et al. Mol Cell Neurosci, 2002 Feb. PMID 11860281
  2. Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes. Al-Sabri MH, et al. Cells, 2022 Nov 8. PMID 36428957, Free PMC Article
  3. PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila. Colomb J, et al. PeerJ, 2016. PMID 27168980, Free PMC Article
  4. Regulation of Drosophila myosin ATPase activity by phosphorylation of myosin light chains--II. Flightless mfd- fly. Takahashi S, et al. Comp Biochem Physiol B, 1990. PMID 2139598
  5. PKC98E Regulates Odorant Responses in Drosophila melanogaster. Poudel S, et al. J Neurosci, 2021 May 5. PMID 33789918, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth in chick retinal ganglion cells.
    Title: Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin light chain kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in flight IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein kinase C delta
Names
CG42349-PC
CG42349-PD
CG42349-PE
Pkcdelta-PC
Pkcdelta-PD
Pkcdelta-PE
myofibrillar defect
protein kinase C
NP_001138191.1
NP_511171.3
NP_572797.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12432224..12453650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078616.4 → NP_511171.3  protein kinase C delta, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511171.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83099, Q5BIE9, Q9VYN2
    UniProtKB/TrEMBL
    B7Z147
    Conserved Domains (3) summary
    smart00220
    Location:343 → 601
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05592
    Location:347 → 666
    STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
    pfam00130
    Location:217 → 269
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_001144719.2 → NP_001138191.1  protein kinase C delta, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83099, Q5BIE9, Q9VYN2
    UniProtKB/TrEMBL
    B7Z147
    Conserved Domains (3) summary
    smart00220
    Location:343 → 601
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05592
    Location:347 → 666
    STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
    pfam00130
    Location:217 → 269
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. NM_132569.3 → NP_572797.3  protein kinase C delta, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572797.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYN1
    Conserved Domains (2) summary
    cd05592
    Location:1570 → 1889
    STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
    pfam05109
    Location:802 → 1131
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z147 B7Z147
P83099.3 P83099
Q9VYN1 Q9VYN1

Gene LinkOut

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