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Sk1 Sphingosine kinase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32089, updated on 10-May-2024

Summary

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Official Symbol
Sk1provided by FlyBase
Official Full Name
Sphingosine kinase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030300
Locus tag
Dmel_CG1747
See related
AllianceGenome:FB:FBgn0030300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1747; Dmel\CG1747; sk1; SK1; Sphk1; SphK1
Summary
Enables D-erythro-sphingosine kinase activity. Involved in phosphorylation and sphingolipid metabolic process. Located in cytosol and plasma membrane. Is expressed in adult head; embryonic/larval midgut; mesoderm; and presumptive embryonic/larval digestive system. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
10B13-10B13; 1-34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11442539..11446012)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11336572..11340045)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Glutamine synthetase 2 Neighboring gene Ecotropic viral integration site 5 Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. Herr DR, et al. J Biol Chem, 2004 Mar 26. PMID 14722126
  2. Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. Yonamine I, et al. J Cell Biol, 2011 Feb 21. PMID 21321100, Free PMC Article
  3. Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology. Walls SM, et al. Dis Model Mech, 2020 Aug 14. PMID 32641420, Free PMC Article
  4. Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. Pantoja M, et al. Development, 2013 Jan 1. PMID 23154413, Free PMC Article
  5. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. McElwain MA, et al. PLoS One, 2011. PMID 22069480, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
    Title: Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-erythro-sphingosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-erythro-sphingosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sphingosine kinase 1
Names
CG1747-PA
CG1747-PB
Sk1-PA
Sk1-PB
sphingosine kinase I
NP_572717.1
NP_727528.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11442539..11446012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167286.2 → NP_727528.1  sphingosine kinase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYY8
    Related
    FBpp0073346
    Conserved Domains (2) summary
    PLN02958
    Location:189 → 622
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
    pfam00781
    Location:191 → 330
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. NM_132489.2 → NP_572717.1  sphingosine kinase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYY8
    Related
    FBpp0073347
    Conserved Domains (2) summary
    PLN02958
    Location:189 → 622
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
    pfam00781
    Location:191 → 330
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYY8 Q9VYY8

Gene LinkOut

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