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Tbcc Tubulin-binding cofactor C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 319048, updated on 18-Sep-2024

Summary

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Official Symbol
Tbccprovided by FlyBase
Official Full Name
Tubulin-binding cofactor Cprovided by FlyBase
Primary source
FLYBASE:FBgn0051961
Locus tag
Dmel_CG31961
See related
AllianceGenome:FB:FBgn0051961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD34582; CG31961; CG3381; Dmel\CG31961; TBCC
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human TBCC (tubulin folding cofactor C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
24D8-24D8; 2-11 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4186250..4187793, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4186250..4187793, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Odorant receptor 24a Neighboring gene long non-coding RNA:CR45791 Neighboring gene long non-coding RNA:CR44057 Neighboring gene lectin-24Db Neighboring gene Nicotinate phosphoribosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity. Jang YG, et al. Mol Cells, 2020 Aug 31. PMID 32759469, Free PMC Article
  2. Arl2- and Msps-dependent microtubule growth governs asymmetric division. Chen K, et al. J Cell Biol, 2016 Mar 14. PMID 26953351, Free PMC Article
  3. A conceptual view at microtubule plus end dynamics in neuronal axons. Voelzmann A, et al. Brain Res Bull, 2016 Sep. PMID 27530065, Free PMC Article
  4. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article
  5. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tubulin-binding cofactor C
Names
CG31961-PA
CG31961-PB
Tbcc-PA
Tbcc-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4186250..4187793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164570.2 → NP_722959.1  Tubulin-binding cofactor C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TP0
    Related
    FBpp0077173
    Conserved Domains (2) summary
    pfam07986
    Location:188 → 306
    TBCC; Tubulin binding cofactor C
    pfam16752
    Location:16 → 128
    TBCC_N; Tubulin-specific chaperone C N-terminal domain

  2. NM_164571.2 → NP_722960.1  Tubulin-binding cofactor C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TP0
    Related
    FBpp0077174
    Conserved Domains (2) summary
    pfam07986
    Location:188 → 306
    TBCC; Tubulin binding cofactor C
    pfam16752
    Location:16 → 128
    TBCC_N; Tubulin-specific chaperone C N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TP0 Q95TP0

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