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Csas CMP-sialic acid synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317923, updated on 18-Sep-2024

Summary

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Official Symbol
Csasprovided by FlyBase
Official Full Name
CMP-sialic acid synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0052220
Locus tag
Dmel_CG32220
See related
AllianceGenome:FB:FBgn0052220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32220; CSAS; DmCSAS; Dmel\CG32220
Summary
Enables N-acylneuraminate cytidylyltransferase activity. Involved in chemical synaptic transmission and response to heat. Located in trans-Golgi network. Is expressed in adult brain; adult head; embryonic/larval central nervous system; and embryonic/larval crystal cell. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
76D8-76D8; 3-46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19988027..19988991, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19981127..19982047, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hale-bopp Neighboring gene schumacher-levy Neighboring gene antisense RNA:CR45161 Neighboring gene flightin Neighboring gene uncharacterized protein Neighboring gene Neurocalcin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties. Mertsalov IB, et al. Biochem J, 2016 Jul 1. PMID 27114558, Free PMC Article
  2. Sialylation and sialyltransferase in insects. Ghosh S. Glycoconj J, 2018 Oct. PMID 30058043
  3. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. Viswanathan K, et al. J Biol Chem, 2006 Jun 9. PMID 16537535
  4. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. Scott H, et al. Elife, 2023 Mar 22. PMID 36946697, Free PMC Article
  5. The role of Drosophila cytidine monophosphate-sialic acid synthetase in the nervous system. Islam R, et al. J Neurosci, 2013 Jul 24. PMID 23884937, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acylneuraminate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylneuraminate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylneuraminate cytidylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CMP-sialic acid synthase
Names
CG32220-PB
CMP-Sialic acid synthetase
Csas-PB
cytidine monophosphate-sialic acid synthetase
NP_730474.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19988027..19988991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168828.3 → NP_730474.2  CMP-sialic acid synthase [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJF3, Q8IQV0
    Conserved Domains (1) summary
    cd02513
    Location:32 → 240
    CMP-NeuAc_Synthase; CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQV0 Q8IQV0

Gene LinkOut

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