Slc4a8 solute carrier family 4 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc4a8provided by RGD
Official Full Name: solute carrier family 4 member 8provided by RGD
Primary source: RGD:735164
See related: Ensembl:ENSRNOG00000028879 AllianceGenome:RGD:735164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; inorganic ion transmembrane transport; and regulation of intracellular pH. Predicted to act upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of membrane potential. Located in several cellular components, including axon; glutamatergic synapse; and synaptic vesicle. Biomarker of prediabetes syndrome. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 56.5), Kidney (RPKM 14.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (133742830..133818056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (131861284..131939295)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (142397352..142467398)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that NDCBE can regulate glutamatergic transmission throughout the brain
Title: The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals.
The sodium-driven chloride/bicarbonate exchanger NDCBE is upregulated in multiple neurons in a cell type-specific manner.
Title: The sodium-driven chloride/bicarbonate exchanger NDCBE in rat brain is upregulated by chronic metabolic acidosis.
Results suggest that Na(+)-driven Cl(-)/HCO(3)(-) exchanger (NCBE) activity is inhibited by protein kinase A and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane.
Title: Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex.

Submit: New GeneRIF Correction

General gene information

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Markers

AI179648 (e-PCR)
- UniSTS:250636

RH142093 (e-PCR)
- UniSTS:224083

AU028023 (e-PCR)
- UniSTS:112735

BF394701 (e-PCR)
- UniSTS:244831

D7Rat90 (e-PCR), detects polymorphism
- UniSTS:228197

BF405593 (e-PCR)
- UniSTS:247940

RH137997 (e-PCR)
- UniSTS:220084

RH134787 (e-PCR)
- UniSTS:218065

BQ201011 (e-PCR)
- UniSTS:260561

BE097103 (e-PCR)
- UniSTS:260566

RH134575 (e-PCR)
- UniSTS:217855

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium,bicarbonate:chloride antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium,bicarbonate:chloride antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium,bicarbonate:chloride antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in basolateral protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic anion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in symmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: electroneutral sodium bicarbonate exchanger 1

Names: Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; electroneutral Na+-driven Cl-HCO3 exchanger; k-NBC3; solute carrier family 4 (anion exchanger), member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270794.3 → NP_001257723.1 electroneutral sodium bicarbonate exchanger 1 isoform 2

See identical proteins and their annotated locations for NP_001257723.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) contains an alternate segment and lacks another alternate segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6KCL9

Conserved Domains (3) summary

TIGR00834
Location:117 → 951

ae; anion exchange protein

pfam00955
Location:445 → 904

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:145 → 404

Band_3_cyto; Band 3 cytoplasmic domain
NM_001270795.3 → NP_001257724.1 electroneutral sodium bicarbonate exchanger 1 isoform 3

See identical proteins and their annotated locations for NP_001257724.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QRW9

Conserved Domains (3) summary

TIGR00834
Location:117 → 926

ae; anion exchange protein

pfam00955
Location:450 → 879

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:145 → 404

Band_3_cyto; Band 3 cytoplasmic domain
NM_001414948.2 → NP_001401877.1 electroneutral sodium bicarbonate exchanger 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

F1LUB7, Q6RVG1, Q6RVG2, Q6RVG3

Related

ENSRNOP00000043825.5, ENSRNOT00000040890.7
NM_199497.4 → NP_955791.1 electroneutral sodium bicarbonate exchanger 1 isoform 1

See identical proteins and their annotated locations for NP_955791.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QRW9

Related

ENSRNOP00000059220.4, ENSRNOT00000065379.4

Conserved Domains (3) summary

TIGR00834
Location:117 → 980

ae; anion exchange protein

pfam00955
Location:450 → 933

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:145 → 404

Band_3_cyto; Band 3 cytoplasmic domain