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Snx27 Sorting nexin 27 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31493, updated on 18-Sep-2024

Summary

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Official Symbol
Snx27provided by FlyBase
Official Full Name
Sorting nexin 27provided by FlyBase
Primary source
FLYBASE:FBgn0052758
Locus tag
Dmel_CG32758
See related
AllianceGenome:FB:FBgn0052758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11465; CG3130; CG3138; CG32758; Dmel\CG32758; DmSNX27; snx27
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
5B2-5B3; 1-13 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5719374..5738031, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5613407..5632064, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42794 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Integrator 6 Neighboring gene Regulator of telomere elongation helicase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Strutt H, et al. Curr Biol, 2019 Feb 4. PMID 30661800, Free PMC Article
  2. Snazarus and its human ortholog SNX25 modulate autophagic flux. Lauzier A, et al. J Cell Sci, 2022 Mar 1. PMID 34821359
  3. SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Zhang P, et al. Cell Res, 2011 Dec. PMID 22041890, Free PMC Article
  4. Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals. Walsh RB, et al. J Cell Biol, 2021 Aug 2. PMID 34019080, Free PMC Article
  5. The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila. Pannen H, et al. Elife, 2020 Dec 30. PMID 33377869, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sorting nexin 27
Names
CG32758-PA
CG32758-PC
CG32758-PD
Snx27-PA
Snx27-PC
Snx27-PD
NP_001259258.1
NP_001284906.1
NP_727023.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5719374..5738031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297977.1 → NP_001284906.1  sorting nexin 27, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JIH1
    Conserved Domains (4) summary
    cd06886
    Location:64 → 169
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd00992
    Location:9 → 37
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:327 → 427
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
    cd01777
    Location:176 → 267
    FERM_F1_SNX27; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 27 (SNX27)

  2. NM_001272329.2 → NP_001259258.1  sorting nexin 27, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259258.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YD98
    Conserved Domains (4) summary
    cd06886
    Location:77 → 182
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd00992
    Location:22 → 50
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:340 → 440
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
    cl00155
    Location:190 → 275
    UBQ; Ubiquitin-like proteins

  3. NM_167045.3 → NP_727023.1  sorting nexin 27, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W486
    Related
    FBpp0070808
    Conserved Domains (4) summary
    cd06886
    Location:165 → 270
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd00992
    Location:46 → 138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:428 → 528
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
    cl00155
    Location:278 → 363
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F3YD98 F3YD98
Q9W486 Q9W486
X2JIH1 X2JIH1

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