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Rexo4 REX4 homolog, 3'-5' exonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 311826, updated on 17-Aug-2024

Summary

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Official Symbol
Rexo4provided by RGD
Official Full Name
REX4 homolog, 3'-5' exonucleaseprovided by RGD
Primary source
RGD:1306220
See related
EnsemblRapid:ENSRNOG00000027867 AllianceGenome:RGD:1306220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Xpmc2h
Summary
Predicted to enable DNA binding activity and nuclease activity. Predicted to be involved in DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; and DNA repair. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in nucleus. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 231.4), Muscle (RPKM 224.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3p13-p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30678729..30692376, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10280654..10291003, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5500578..5510908, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene surfeit 2 Neighboring gene surfeit 4 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 13 Neighboring gene uncharacterized LOC102548484 Neighboring gene calcium channel flower domain containing 1 Neighboring gene solute carrier family 2 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. Krishnamurthy N, et al. Oncogene, 2011 Nov 24. PMID 21602889, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA exonuclease 4
Names
REX4, RNA exonuclease 4 homolog
XPMC2 prevents mitotic catastrophe 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033884.1 → NP_001029056.1  RNA exonuclease 4

    See identical proteins and their annotated locations for NP_001029056.1

    Status: VALIDATED

    Source sequence(s)
    AI059073, BM391409, CB557415, CB611468, CB800860, CO563573
    UniProtKB/TrEMBL
    B1WBN4, F7ESM1
    Related
    ENSRNOP00000043432.4, ENSRNOT00000042289.7
    Conserved Domains (2) summary
    cd06144
    Location:231 → 381
    REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
    COG0847
    Location:228 → 392
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30678729..30692376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010064643.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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