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Sccpdh saccharopine dehydrogenase (putative) [ Rattus norvegicus (Norway rat) ]

Gene ID: 305021, updated on 2-May-2024

Summary

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Symbol
Sccpdhprovided by RGD
Full Name
saccharopine dehydrogenase (putative)provided by RGD
Primary source
RGD:1311440
See related
Ensembl:ENSRNOG00000066712 AllianceGenome:RGD:1311440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311440
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Predicted to be located in midbody. Predicted to be active in lipid droplet. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 739.4), Liver (RPKM 508.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sccpdh in Genome Data Viewer
Location:
13q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93932086..93953840)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91400120..91421875)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97941720..97963474)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transcription factor B2, mitochondrial Neighboring gene uncharacterized LOC108352581 Neighboring gene consortin, connexin sorting protein Neighboring gene kinesin family member 28, pseudogene Neighboring gene AT hook containing transcription factor 1 Neighboring gene uncharacterized LOC134481630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto Y, et al. Biochim Biophys Acta, 2004 Feb 2. PMID 14741744
  2. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
  3. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
  4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
saccharopine dehydrogenase-like oxidoreductase
Names
probable saccharopine dehydrogenase
NP_001014007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013985.1 → NP_001014007.1  saccharopine dehydrogenase-like oxidoreductase

    See identical proteins and their annotated locations for NP_001014007.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079215
    UniProtKB/Swiss-Prot
    Q6AY30
    UniProtKB/TrEMBL
    A0A8L2QQT2, A6JGF6
    Related
    ENSRNOP00000003791.4, ENSRNOT00000003791.7
    Conserved Domains (1) summary
    COG3268
    Location:1 → 421
    COG3268; Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    93932086..93953840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY30.1 GenPept UniProtKB/Swiss-Prot:Q6AY30

Gene LinkOut

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