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Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304282, updated on 17-Aug-2024

Summary

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Official Symbol
Baiap2l1provided by RGD
Official Full Name
BAR/IMD domain containing adaptor protein 2 like 1provided by RGD
Primary source
RGD:1308452
See related
EnsemblRapid:ENSRNOG00000001007 AllianceGenome:RGD:1308452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308452
Summary
Predicted to enable proline-rich region binding activity. Predicted to be involved in actin filament organization; positive regulation of cytoskeleton organization; and response to bacterium. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with actin cytoskeleton. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 76.5), Liver (RPKM 67.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Baiap2l1 in Genome Data Viewer
Location:
12p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15364090..15453602)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10250434..10339937)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12226967..12321172)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L15 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Aitio O, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21098279, Free PMC Article
  2. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Vingadassalom D, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366662, Free PMC Article
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124996

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables proline-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Names
BAI1-associated protein 2-like 1
BAI1-associated protein 2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034140.1 → NP_001029312.1  BAR/IMD domain-containing adapter protein 2-like 1

    See identical proteins and their annotated locations for NP_001029312.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105815
    UniProtKB/Swiss-Prot
    Q3KR97, Q5FWT2
    UniProtKB/TrEMBL
    A0A8L2QTC2
    Related
    ENSRNOP00000075796.3, ENSRNOT00000092610.3
    Conserved Domains (2) summary
    cd07645
    Location:6 → 231
    I-BAR_IMD_BAIAP2L1; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1
    cd11913
    Location:343 → 400
    SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15364090..15453602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598315.3 → XP_017453804.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QTC2
    Related
    ENSRNOP00000057568.6, ENSRNOT00000060843.6

  2. XM_063271253.1 → XP_063127323.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2RB03

  3. XM_063271254.1 → XP_063127324.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3

  4. XM_039089346.2 → XP_038945274.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3

    Conserved Domains (4) summary
    cd11913
    Location:234 → 291
    SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)
    cd21762
    Location:393 → 396
    WH2; actin-binding sequence [structural motif]
    cl12013
    Location:1 → 117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl41728
    Location:391 → 406
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KR97.1 GenPept UniProtKB/Swiss-Prot:Q3KR97

Gene LinkOut

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