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Igsf1 immunoglobulin superfamily, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302822, updated on 6-Jun-2024

Summary

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Official Symbol
Igsf1provided by RGD
Official Full Name
immunoglobulin superfamily, member 1provided by RGD
Primary source
RGD:631402
See related
Ensembl:ENSRNOG00000007600 AllianceGenome:RGD:631402
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Inhbp
Summary
Enables coreceptor activity. Predicted to be involved in negative regulation of activin receptor signaling pathway and regulation of transcription, DNA-templated. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in IGSF1 deficiency syndrome. Orthologous to human IGSF1 (immunoglobulin superfamily member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 103.3), Adrenal (RPKM 69.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Igsf1 in Genome Data Viewer
Location:
Xq36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (133947717..133963154, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (129069891..129085331, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (136792637..136808107, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily Q member 2 Neighboring gene olfactory receptor family 5 subfamily O member 1 Neighboring gene olfactory receptor family 11 subfamily N member 2 Neighboring gene olfactory receptor family 5 subfamily BH member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat. Joustra SD, et al. J Endocrinol, 2015 Sep. PMID 26163525
  2. Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle. Bernard DJ, et al. Mol Endocrinol, 2001 Apr. PMID 11266515
  3. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. Wang Y, et al. PLoS One, 2017. PMID 28686733, Free PMC Article
  4. Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). Chapman SC, et al. Mol Endocrinol, 2001 Apr. PMID 11266516
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156568

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables activin receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
  
enables activin receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inhibin binding IEA
Inferred from Electronic Annotation
more info
  
enables inhibin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 1
Names
inhibin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175763.2 → NP_786939.1  immunoglobulin superfamily member 1 precursor

    See identical proteins and their annotated locations for NP_786939.1

    Status: PROVISIONAL

    Source sequence(s)
    AF322216
    UniProtKB/Swiss-Prot
    A0JPK8, Q925N5, Q925N6
    UniProtKB/TrEMBL
    A0A8L2Q5H1, A6JMS1
    Related
    ENSRNOP00000010325.5, ENSRNOT00000010325.6
    Conserved Domains (2) summary
    smart00410
    Location:772 → 852
    IG_like; Immunoglobulin like
    cl11960
    Location:1145 → 1231
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    133947717..133963154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279962.1 → XP_063136032.1  immunoglobulin superfamily member 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  2. XM_063279959.1 → XP_063136029.1  immunoglobulin superfamily member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  3. XM_063279960.1 → XP_063136030.1  immunoglobulin superfamily member 1 isoform X3

    UniProtKB/Swiss-Prot
    A0JPK8, Q925N5, Q925N6
    UniProtKB/TrEMBL
    A0A8L2Q5H1, A6JMS1

  4. XM_006257557.4 → XP_006257619.1  immunoglobulin superfamily member 1 isoform X1

    See identical proteins and their annotated locations for XP_006257619.1

    UniProtKB/TrEMBL
    A0A8L2Q5H1
    Conserved Domains (2) summary
    smart00410
    Location:781 → 861
    IG_like; Immunoglobulin like
    cl11960
    Location:1154 → 1240
    Ig; Immunoglobulin domain

  5. XM_063279965.1 → XP_063136035.1  immunoglobulin superfamily member 1 isoform X10

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  6. XM_006257561.3 → XP_006257623.1  immunoglobulin superfamily member 1 isoform X9

    UniProtKB/TrEMBL
    A0A8L2Q5H1
    Conserved Domains (2) summary
    smart00410
    Location:781 → 861
    IG_like; Immunoglobulin like
    cl11960
    Location:1058 → 1144
    Ig; Immunoglobulin domain

  7. XM_063279961.1 → XP_063136031.1  immunoglobulin superfamily member 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  8. XM_006257558.3 → XP_006257620.1  immunoglobulin superfamily member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q5H1
    Conserved Domains (2) summary
    smart00410
    Location:780 → 860
    IG_like; Immunoglobulin like
    cl11960
    Location:1153 → 1239
    Ig; Immunoglobulin domain

  9. XM_063279963.1 → XP_063136033.1  immunoglobulin superfamily member 1 isoform X6

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  10. XM_063279964.1 → XP_063136034.1  immunoglobulin superfamily member 1 isoform X8

    UniProtKB/TrEMBL
    A0A8L2Q5H1

  11. XM_006257559.3 → XP_006257621.1  immunoglobulin superfamily member 1 isoform X5

    UniProtKB/TrEMBL
    A0A8L2Q5H1
    Conserved Domains (2) summary
    smart00410
    Location:752 → 832
    IG_like; Immunoglobulin like
    cl11960
    Location:1125 → 1211
    Ig; Immunoglobulin domain

  12. XM_006257560.3 → XP_006257622.1  immunoglobulin superfamily member 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ATC3, A0A8L2Q5H1
    Related
    ENSRNOP00000097633.1
    Conserved Domains (2) summary
    smart00410
    Location:781 → 861
    IG_like; Immunoglobulin like
    cl11960
    Location:1154 → 1240
    Ig; Immunoglobulin domain

  13. XM_008773563.3 → XP_008771785.1  immunoglobulin superfamily member 1 isoform X1

    See identical proteins and their annotated locations for XP_008771785.1

    UniProtKB/TrEMBL
    A0A8L2Q5H1
    Conserved Domains (2) summary
    smart00410
    Location:781 → 861
    IG_like; Immunoglobulin like
    cl11960
    Location:1154 → 1240
    Ig; Immunoglobulin domain

  14. XM_039099678.1 → XP_038955606.1  immunoglobulin superfamily member 1 isoform X11

    UniProtKB/TrEMBL
    A6JMS3
    Conserved Domains (2) summary
    cd00096
    Location:122 → 128
    Ig; Ig strand A [structural motif]
    cl11960
    Location:121 → 211
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925N6.1 GenPept UniProtKB/Swiss-Prot:Q925N6

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