gjc4b gap junction protein gamma 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gjc4bprovided by ZNC
Official Full Name: gap junction protein gamma 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-38
See related: Ensembl:ENSDARG00000007099 AllianceGenome:ZFIN:ZDB-GENE-990415-38
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gja7; gjc1; cb232; cx43.4; wu:fc46h11
Summary: Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in gap junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of connexin complex. Is expressed in several structures, including central nervous system; immature eye; mesoderm; neural tube; and tail bud. Orthologous to human GJC1 (gap junction protein gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (46405587..46415813, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (46605108..46615334, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We report here on the biochemical and immunohistochemical characterization of zebrafish connexin zfCx43.4, an orthologue of mammalian and avian Cx45, and the electrophysiological properties of junctional channels formed by this protein.
Title: Characterization of zebrafish Cx43.4 connexin and its channels.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc46h11.x1 (e-PCR)
- UniSTS:188196

L46801 (e-PCR)
- UniSTS:205350

fi27f08.x1 (e-PCR)
- UniSTS:197160

L46801 (e-PCR)
- UniSTS:205660

Z10789 (e-PCR)
- UniSTS:204642

dermo1 (e-PCR), detects polymorphism
- UniSTS:204647

fe15b04.y1 (e-PCR)
- UniSTS:196217

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: gap junction gamma-1 protein

Names: connexin 43.4; gap junction alpha-7 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131069.2 → NP_571144.2 gap junction gamma-1 protein

See identical proteins and their annotated locations for NP_571144.2

Status: PROVISIONAL

Source sequence(s)

BC044357

UniProtKB/Swiss-Prot

Q92052, Q92053

UniProtKB/TrEMBL

Q803S5

Related

ENSDARP00000015225.7, ENSDART00000009790.9

Conserved Domains (3) summary

smart00037
Location:42 → 75

CNX; Connexin homologues

smart01089
Location:183 → 249

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:2 → 250

Connexin; Connexin