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Arb2a ARB2 cotranscriptional regulator A [ Rattus norvegicus (Norway rat) ]

Gene ID: 294606, updated on 6-Jun-2024

Summary

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Official Symbol
Arb2aprovided by RGD
Official Full Name
ARB2 cotranscriptional regulator Aprovided by RGD
Primary source
RGD:1305526
See related
Ensembl:ENSRNOG00000013844 AllianceGenome:RGD:1305526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam172a; RGD1305526
Summary
Predicted to contribute to siRNA binding activity. Predicted to be involved in heterochromatin assembly by small RNA; neural crest cell development; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human FAM172A (family with sequence similarity 172 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 168.8), Lung (RPKM 111.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arb2a in Genome Data Viewer
Location:
2q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (9289694..9753991)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (7553873..8018183)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (4942795..5547744)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene KIAA0825 homolog Neighboring gene ribosomal protein L17, pseudogene 12 Neighboring gene ribosomal protein L35, pseudogene 3 Neighboring gene mRNA turnover protein 4 homolog Neighboring gene RNA, U6 small nuclear 259 Neighboring gene POU domain class 5, transcription factor 2 Neighboring gene protein FAM98B-like Neighboring gene nuclear receptor subfamily 2, group F, member 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell. Andersen B, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 7902581, Free PMC Article
  2. Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Bélanger C, et al. Proc Natl Acad Sci U S A, 2018 Jan 23. PMID 29311329, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to siRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cotranscriptional regulator ARB2A
Names
cotranscriptional regulator FAM172A
family with sequence similarity 172, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106401.1 → NP_001099871.1  cotranscriptional regulator ARB2A

    See identical proteins and their annotated locations for NP_001099871.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473955
    UniProtKB/TrEMBL
    A0A1W2Q630, A0A8I6ALB8, A6I4H2
    Related
    ENSRNOP00000076112.1, ENSRNOT00000093741.2
    Conserved Domains (1) summary
    pfam09757
    Location:32 → 176
    Arb2; Arb2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    9289694..9753991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281474.1 → XP_063137544.1  cotranscriptional regulator ARB2A isoform X6

  2. XM_063281479.1 → XP_063137549.1  cotranscriptional regulator ARB2A isoform X11

  3. XM_063281481.1 → XP_063137551.1  cotranscriptional regulator ARB2A isoform X13

  4. XM_039101899.2 → XP_038957827.1  cotranscriptional regulator ARB2A isoform X3

  5. XM_063281470.1 → XP_063137540.1  cotranscriptional regulator ARB2A isoform X2

  6. XM_063281475.1 → XP_063137545.1  cotranscriptional regulator ARB2A isoform X7

  7. XM_063281483.1 → XP_063137553.1  cotranscriptional regulator ARB2A isoform X16

  8. XM_039101894.2 → XP_038957822.1  cotranscriptional regulator ARB2A isoform X1

  9. XM_008760626.4 → XP_008758848.2  cotranscriptional regulator ARB2A isoform X14

    UniProtKB/TrEMBL
    A0A8I5Y692
    Related
    ENSRNOP00000093689.1

  10. XM_063281472.1 → XP_063137542.1  cotranscriptional regulator ARB2A isoform X4

  11. XM_063281473.1 → XP_063137543.1  cotranscriptional regulator ARB2A isoform X4

  12. XM_063281471.1 → XP_063137541.1  cotranscriptional regulator ARB2A isoform X4

  13. XM_039101903.2 → XP_038957831.1  cotranscriptional regulator ARB2A isoform X5

    UniProtKB/TrEMBL
    A0A1W2Q607, A0A8I6GH74
    Related
    ENSRNOP00000089372.1

  14. XM_063281480.1 → XP_063137550.1  cotranscriptional regulator ARB2A isoform X12

    UniProtKB/TrEMBL
    A0A1W2Q607

  15. XM_063281477.1 → XP_063137547.1  cotranscriptional regulator ARB2A isoform X9

    UniProtKB/TrEMBL
    A0A1W2Q607, A0A8I5ZU52

  16. XM_063281484.1 → XP_063137554.1  cotranscriptional regulator ARB2A isoform X17

    UniProtKB/TrEMBL
    A0A8I5Y692, A0A8I6AKD2

  17. XM_063281482.1 → XP_063137552.1  cotranscriptional regulator ARB2A isoform X15

    UniProtKB/TrEMBL
    A0A8I5Y692

  18. XM_063281485.1 → XP_063137555.1  cotranscriptional regulator ARB2A isoform X18

    UniProtKB/TrEMBL
    A0A8I5Y692

  19. XM_063281478.1 → XP_063137548.1  cotranscriptional regulator ARB2A isoform X10

    UniProtKB/TrEMBL
    A0A1W2Q607

  20. XM_063281476.1 → XP_063137546.1  cotranscriptional regulator ARB2A isoform X8

    UniProtKB/TrEMBL
    A0A1W2Q607
Nucleotide Protein Strain
Heading Accession and Version

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