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Mcoln2 mucolipin TRP cation channel 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292168, updated on 5-Mar-2024

Summary

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Official Symbol
Mcoln2provided by RGD
Official Full Name
mucolipin TRP cation channel 2provided by RGD
Primary source
RGD:1308884
See related
Ensembl:ENSRNOG00000015089 AllianceGenome:RGD:1308884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAADP-sensitive calcium-release channel activity and identical protein binding activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within myeloid leukocyte migration and positive regulation of chemokine production. Predicted to be located in recycling endosome. Predicted to be active in membrane. Orthologous to human MCOLN2 (mucolipin TRP cation channel 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 61.9), Kidney (RPKM 28.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcoln2 in Genome Data Viewer
Location:
2q44
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237714100..237762979)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235053816..235102703)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252018594..252068209)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synapse defective Rho GTPase homolog 2 Neighboring gene mucolipin TRP cation channel 3 Neighboring gene dynein axonemal intermediate chain 3 Neighboring gene lysophosphatidic acid receptor 3 Neighboring gene RNA, U6 small nuclear 777

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel Role of TRPML2 in the Regulation of the Innate Immune Response. Sun L, et al. J Immunol, 2015 Nov 15. PMID 26432893, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124828

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAADP-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within macrophage migration ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemokine (C-C motif) ligand 5 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of macrophage inflammatory protein 1 alpha production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
NOT is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mucolipin-2
Names
mucolipin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039005.1 → NP_001034094.1  mucolipin-2

    See identical proteins and their annotated locations for NP_001034094.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099787
    UniProtKB/TrEMBL
    A6HWD2, Q499S1
    Related
    ENSRNOP00000020452.5, ENSRNOT00000020452.7
    Conserved Domains (1) summary
    pfam08016
    Location:380 → 513
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    237714100..237762979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101881.2 → XP_038957809.1  mucolipin-2 isoform X1

    UniProtKB/TrEMBL
    A6HWD2
    Conserved Domains (2) summary
    pfam08016
    Location:331 → 464
    PKD_channel; Polycystin cation channel
    cl41763
    Location:62 → 226
    ELD_TRPML; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)
Nucleotide Protein Strain
Heading Accession and Version

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