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Oxsm 3-oxoacyl-ACP synthase, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 289934, updated on 17-Aug-2024

Summary

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Official Symbol
Oxsmprovided by RGD
Official Full Name
3-oxoacyl-ACP synthase, mitochondrialprovided by RGD
Primary source
RGD:1311092
See related
AllianceGenome:RGD:1311092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311092
Summary
Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Predicted to be located in cytosol and mitochondrion. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 26.9), Kidney (RPKM 22.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (11641177..11645370)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (9210443..9215852)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (10462380..10466496)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase II beta Neighboring gene N-glycanase 1 Neighboring gene uncharacterized LOC120097102 Neighboring gene uncharacterized LOC134481945

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang L, et al. J Biol Chem, 2005 Apr 1. PMID 15668256
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
NP_001093978.1
XP_006251773.1
XP_038949017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100508.1 → NP_001093978.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

    See identical proteins and their annotated locations for NP_001093978.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K049, G3V6R7
    Conserved Domains (1) summary
    cl09938
    Location:38 → 451
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    11641177..11645370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093089.2 → XP_038949017.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6K049, G3V6R7
    Conserved Domains (1) summary
    cl09938
    Location:38 → 451
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  2. XM_006251711.4 → XP_006251773.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006251773.1

    UniProtKB/TrEMBL
    A6K049, G3V6R7
    Conserved Domains (1) summary
    cl09938
    Location:38 → 451
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
Nucleotide Protein Strain
Heading Accession and Version

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