OPN1LW opsin 1, long wave sensitive [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: OPN1LW
Gene description: opsin 1, long wave sensitive
See related: BGD:BT27788; Ensembl:ENSBTAG00000020299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: OPSN
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Genomic context

Location:: chromosome: X

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (37321404..37333672)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an extended network of hydrogen bonds connects the agonist retinal binding site to the G protein binding site via conserved amino acid residues. dynamics of the hydrogen-bonding network inside opsin couples to interactions at the G protein binding site
Title: Dynamics of bovine opsin bound to G-protein fragments.
instability of the retinitis pigmentosa P23H mutant opsin
Title: Inherent instability of the retinitis pigmentosa P23H mutant opsin.
a single dibasic degron motif is sufficient to initiate both the ER retention and subsequent degradation of ospin via an endoplasmic reticulum associated degradation pathway
Title: Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein.
the crystal structure of ligand-free native opsin from bovine retinal rod cells at 2.9 angstrom (A) resolution
Title: Crystal structure of the ligand-free G-protein-coupled receptor opsin.
Mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx.
Title: Calnexin is not essential for mammalian rod opsin biogenesis.
3.2 A crystal structure of the bovine Ops*-GalphaCT peptide complex
Title: Crystal structure of opsin in its G-protein-interacting conformation.
Ligand binding in opsin apparently follows an induced-fit three-point interaction model, with the ring, 9-methyl group, and aldehyde group as the determining selection elements.
Title: Constraints of the 9-methyl group binding pocket of the rhodopsin chromophore probed by 9-halogeno substitution.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phototransduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: long-wave-sensitive opsin 1

Names: opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan); red cone photoreceptor pigment; red-sensitive opsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174566.1 → NP_776991.1 long-wave-sensitive opsin 1

See identical proteins and their annotated locations for NP_776991.1

Status: PROVISIONAL

Source sequence(s)

AF280398

UniProtKB/Swiss-Prot

Q9BGI7

Related

ENSBTAP00000027054.2, ENSBTAT00000027054.3

Conserved Domains (2) summary

cd14964
Location:56 → 80

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:42 → 333

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily