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LDLR low density lipoprotein receptor [ Bos taurus (domestic cattle) ]

Gene ID: 281276, updated on 17-Aug-2024

Summary

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Official Symbol
LDLRprovided by VGNC
Official Full Name
low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:55214
See related
BGD:BT12341; Ensembl:ENSBTAG00000012314
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15545371..15579082)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene microRNA mir-2882 Neighboring gene U6 spliceosomal RNA Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. Schneider WJ, et al. J Cell Biol, 1983 Nov. PMID 6313699, Free PMC Article
  2. cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. Russell DW, et al. Proc Natl Acad Sci U S A, 1983 Dec. PMID 6143315, Free PMC Article
  3. Molecular cloning of bovine LDL receptor cDNAs. Russell DW, et al. Methods Enzymol, 1986. PMID 3755212
  4. Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene. Hobbs HH, et al. Proc Natl Acad Sci U S A, 1985 Nov. PMID 2999774, Free PMC Article
  5. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Candela P, et al. Endothelium, 2008 Sep-Oct. PMID 19065317

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor
Names
LDL receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166530.1 → NP_001160002.1  low-density lipoprotein receptor precursor

    See identical proteins and their annotated locations for NP_001160002.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000007
    UniProtKB/Swiss-Prot
    F1MZ58, P01131
    UniProtKB/TrEMBL
    A0A3Q1LYY5
    Related
    ENSBTAP00000016342.4, ENSBTAT00000016342.6
    Conserved Domains (5) summary
    smart00135
    Location:555 → 597
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 386
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:673 → 713
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    15545371..15579082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010806777.4 → XP_010805079.1  low-density lipoprotein receptor isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LYY5, A0A3Q1NG72
    Related
    ENSBTAP00000070785.1, ENSBTAT00000082171.2
    Conserved Domains (5) summary
    smart00135
    Location:514 → 556
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:315 → 345
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:490 → 530
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:632 → 672
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_059887926.1 → XP_059743909.1  low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LYY5, A0A3Q1NKK1
    Related
    ENSBTAP00000072874.1, ENSBTAT00000078108.2

  3. XM_059887927.1 → XP_059743910.1  low-density lipoprotein receptor isoform X3

    UniProtKB/TrEMBL
    A0AAA9TXM8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01131.2 GenPept UniProtKB/Swiss-Prot:P01131

Gene LinkOut

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