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UL46 tegument protein VP11/12 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703413, updated on 20-Nov-2023

Summary

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Gene symbol
UL46
Gene description
tegument protein VP11/12
Locus tag
HHV1gp00p29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (98727..100953, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene envelope protein UL43 Neighboring gene envelope glycoprotein C Neighboring gene membrane protein UL45 Neighboring gene tegument protein VP13/14 Neighboring gene transactivating tegument protein VP16 Neighboring gene envelope glycoprotein N Neighboring gene tegument protein VP22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4(+) T(EM) Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in "Humanized" HLA-DR Transgenic Mice. Srivastava R, et al. J Virol, 2020 Mar 17. PMID 31915285, Free PMC Article
  2. Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling. You H, et al. mBio, 2019 May 21. PMID 31113902, Free PMC Article
  3. Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency. Vink EI, et al. J Virol, 2018 Dec 15. PMID 30282708, Free PMC Article
  4. Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2. Lahmidi S, et al. Virology, 2017 Nov. PMID 28841444
  5. Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1. Deschamps T, et al. J Virol, 2017 Aug 15. PMID 28592536, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4(+) TEM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in ""Humanized"" HLA-DR Transgenic Mice.
    Title: Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4(+) T(EM) Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in "Humanized" HLA-DR Transgenic Mice.
  2. Here, HSV-1 tegument protein UL46 was demonstrated to downregulate TBK1-dependent antiviral innate immunity. UL46 interacted with TBK1 and reduced TBK1 activation and its downstream signaling.
    Title: Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling.
  3. Study identifies an unexpected function for UL46 in supporting virus reproduction during physiological stress and identifies a new class of virus-encoded mTORC1 regulators that selectively uncouple mTORC1 activation from amino acid sufficiency.
    Title: Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency.
  4. In this report, the authors demonstrated that the cellular adaptor proteins Dok-2 and Dok-1 are tyrosine phosphorylated upon herpes simplex virus 1 infection. In addition, herpes simplex virus 1 induced the selective degradation of Dok-2. Finally, Dok-2 interacts with herpes simplex virus 1 VP11/12, and that herpes simplex virus 1-induced tyrosine phosphorylation and degradation of Dok-2 require VP11/12.
    Title: Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2.
  5. The authors found that the herpes simplex virus 1 UL46 protein interacts with and colocalizes with STING.
    Title: Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1.
  6. pUL46 is partially degraded in a proteasome-mediated manner during infection, and that the catalytic activity of ICP0 is responsible for this degradation.
    Title: A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection.
  7. VP11/12 SFK-binding motifs recruit Lck and the activated Src family kinase then leads (directly or indirectly) to phosphorylation of additional motifs involved in recruiting p85, Grb2, and Shc.
    Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.
  8. Here, the authors show that VP11/12 is required for virus-induced activation of PI3K-Akt signaling in herpes simplex virus 1-infected Jurkat T cells and primary fibroblasts.
    Title: Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.
  9. In contrast, VP11/12 interacted with Lck or Lck signaling complexes and was strictly required for Lck activation during herpes simplex virus 1 infection.
    Title: Herpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: c98732-98727 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
tegument protein VP11/12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    98727..100953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137121.1 tegument protein VP11/12 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137121.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQH4, O09799, P10230, Q09I88
    UniProtKB/TrEMBL
    A0A5J6DWA2, A0A5J6DWJ0, A0A7S4U3Y4, G8HBG0
    Conserved Domains (1) summary
    PHA03321
    Location:1 → 718
    PHA03321; tegument protein VP11/12; Provisional
Nucleotide Protein
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