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US4 envelope glycoprotein G [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703404, updated on 18-Aug-2023

Summary

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Gene symbol
US4
Gene description
envelope glycoprotein G
Locus tag
HHV1gp00p11
Gene type
protein coding
RNA name
envelope glycoprotein G
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (136705..137534)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene regulatory protein ICP22 Neighboring gene virion protein US2 Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein J Neighboring gene envelope glycoprotein D Neighboring gene envelope glycoprotein I Neighboring gene envelope glycoprotein E Neighboring gene membrane protein US8A Neighboring gene membrane protein US9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low pH-induced conformational change in herpes simplex virus glycoprotein B. Dollery SJ, et al. J Virol, 2010 Apr. PMID 20147407, Free PMC Article
  2. Herpes simplex virus particles interact with chemokines and enhance cell migration. Martínez-Martín N, et al. J Gen Virol, 2016 Nov. PMID 27692045
  3. Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. Atanasiu D, et al. J Virol, 2010 Apr. PMID 20130048, Free PMC Article
  4. Evolution of sexually transmitted and sexually transmissible human herpesviruses. Davison AJ. Ann N Y Acad Sci, 2011 Aug. PMID 22417106

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gG is the envelope glycoprotein mediating interaction with chemokines and enhance cell migration.
    Title: Herpes simplex virus particles interact with chemokines and enhance cell migration.
  2. Upon triggering by gD, gB fusion loops are inserted into target lipid membranes. gB then interacts with gH/gL, and this interaction is eventually followed by fusion.
    Title: Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion.
  3. Here the authors demonstrate that mildly acidic pH triggers specific conformational changes in herpes simplex virus (HSV) gB.
    Title: Low pH-induced conformational change in herpes simplex virus glycoprotein B.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: 136705-136710 regulatory_class = TATA_box
  • Loc: 137511-137516 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope glycoprotein G
YP_009137139.1
  • gD family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    136705..137534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137139.1 envelope glycoprotein G [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137139.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06484, Q770H5
    UniProtKB/TrEMBL
    A0A181ZH73, A0A181ZHJ3, A0A5C2GZ12, A0A5C2H1I2, A0A5C2H435, A0A5J6DVG3, G8H8Q4, G8HBH8, Q7TI17, Q9W891
    Conserved Domains (1) summary
    PHA03247
    Location:23 → 177
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
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