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UL21 tegument protein UL21 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703372, updated on 31-Jan-2024

Summary

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Gene symbol
UL21
Gene description
tegument protein UL21
Locus tag
HHV1gp00p55
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (42075..43696)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene DNA packaging terminase subunit 1 Neighboring gene tegument protein UL16 Neighboring gene DNA packaging tegument protein UL17 Neighboring gene capsid triplex subunit 2 Neighboring gene major capsid protein Neighboring gene envelope protein UL20 Neighboring gene envelope glycoprotein H Neighboring gene involved in nucleotide metabolism Neighboring gene nuclear protein UL24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy. Ma Z, et al. Autophagy, 2023 May. PMID 36343628, Free PMC Article
  2. Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21. Metrick CM, et al. J Virol, 2016 Jun 15. PMID 27053559, Free PMC Article
  3. The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein. Metrick CM, et al. J Virol, 2015 Mar. PMID 25540382, Free PMC Article
  4. Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle. Mbong EF, et al. J Virol, 2012 Jun. PMID 22496211, Free PMC Article
  5. Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus. Harper AL, et al. J Virol, 2010 Mar. PMID 20042500, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
    Title: Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
  2. determined the crystal structure of the C-terminal domain of UL21; the unexpected RNA-binding ability of UL21 may expand its functional repertoire. The structure of UL21C and the observation of its RNA-binding ability are the latest additions to the navigational chart that can guide the exploration of the multiple functions of UL21.
    Title: Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
  3. Authors determined the crystal structure of the conserved N-terminal domain of UL21 from herpes simplex virus 1 to 2.0-A resolution, which revealed a novel sail-like protein fold.
    Title: The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.
  4. Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication.
    Title: Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle.
  5. Data show that UL21 and UL16 can form a complex in the absence of other viral proteins, and that UL16 must have two distinct binding sites.
    Title: Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 43691-43696 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
tegument protein UL21

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    42075..43696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137095.1 tegument protein UL21 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137095.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQE8, P10205, Q09IB2
    UniProtKB/TrEMBL
    A0A0B5ECX0, A0A0F7GUB9, A0A0F7GX87, A0A181ZHI8, A0A181ZHP3, A0A193GX46, A0A1C6W6G2, A0A2U9ACA6, A0A2Z4H0E5, A0A2Z4HBV8, F8RFA5, F8RFH6, F8RG07, F8RG50
    Conserved Domains (1) summary
    cl28056
    Location:1 → 522
    Herpes_UL21; Herpesvirus UL21
Nucleotide Protein
Heading Accession and Version

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