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din1 RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542540, updated on 18-Sep-2024

Summary

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Official Symbol
din1
Official Full Name
RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1
Primary source
PomBase:SPAC19D5.06c
Locus tag
SPOM_SPAC19D5.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rai1
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5220220..5221494, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Imp3 Neighboring gene uncharacterized protein Neighboring gene DNA replication factor C complex subunit Ctf8 Neighboring gene mitophagy receptor Atg43 Neighboring gene 4-aminobutyrate aminotransferase (GABA transaminase) Neighboring gene ncRNA Neighboring gene Smc5-6 complex SMC P-loop ATPase subunit Smc5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32374864, Free PMC Article
  2. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Xiang S, et al. Nature, 2009 Apr 9. PMID 19194460, Free PMC Article
  3. The dhp1(+) gene, encoding a putative nuclear 5'-->3' exoribonuclease, is required for proper chromosome segregation in fission yeast. Shobuike T, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11238999, Free PMC Article
  4. 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO. Picard-Jean F, et al. PLoS One, 2018. PMID 29601584, Free PMC Article
  5. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31777937, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
    Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-hydroxyl dinucleotide hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA NAD+-cap (NAD+-forming) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphodiesterase decapping endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD-cap decapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD-cap decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IC
Inferred by Curator
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Las1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5220220..5221494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020334.3 → NP_594904.1  RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594904.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13836
    Conserved Domains (1) summary
    pfam08652
    Location:200 → 283
    RAI1; RAI1 like PD-(D/E)XK nuclease
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials