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hhp2 serine/threonine protein kinase Hhp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541929, updated on 20-May-2024

Summary

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Gene symbol
hhp2
Gene description
serine/threonine protein kinase Hhp2
Primary source
PomBase:SPAC23C4.12
Locus tag
SPAC23C4.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See hhp2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (1048957..1051136)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene putative guanyl-nucleotide exchange factor Sec2 Neighboring gene miscRNA Neighboring gene putative F0-ATPase subunit J Neighboring gene putative SNARE protein Bet1 Neighboring gene putative mannosyltransferase complex subunit Alg1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Casein kinase 1 is required for efficient removal of Rec8 during meiosis I. Rumpf C, et al. Cell Cycle, 2010 Jul 1. PMID 20581463, Free PMC Article
  2. Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair. Dhillon N, et al. EMBO J, 1994 Jun 15. PMID 8026462, Free PMC Article
  3. The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole. Elmore ZC, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742018, Free PMC Article
  4. Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. Brookheart RT, et al. J Biol Chem, 2014 Jan 31. PMID 24327658, Free PMC Article
  5. Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity. Hoekstra MF, et al. Mol Biol Cell, 1994 Aug. PMID 7803855, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We describe our isolation and characterization of the casein kinase 1 family member Hhp2 as a novel regulator of Sre1N.
    Title: Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic sister chromatid arm separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of linear element assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase Hhp2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1048957..1051136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018580.2 → NP_593184.1  serine/threonine protein kinase Hhp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593184.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40236
    Conserved Domains (2) summary
    COG0515
    Location:11 → 353
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:11 → 283
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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Gene LinkOut

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Research Materials