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mtr4 TRAMP complex ATP-dependent RNA helicase subunit Mtr4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541639, updated on 11-Apr-2024

Summary

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Gene symbol
mtr4
Gene description
TRAMP complex ATP-dependent RNA helicase subunit Mtr4
Primary source
PomBase:SPAC6F12.16c
Locus tag
SPAC6F12.16c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (1344924..1348614, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulatory subunit Par2 Neighboring gene geranyltranstransferase Fps1 Neighboring gene anaphase-promoting complex subunit Apc8 Neighboring gene anaphase-promoting complex subunit Cut9 Neighboring gene miscRNA Neighboring gene putative cleavage and polyadenylation specificity factor complex subunit Rna14 Neighboring gene nucleoporin Nup40

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Bühler M, et al. Cell, 2007 May 18. PMID 17512405
  2. A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. Lemieux C, et al. Mol Cell, 2011 Oct 7. PMID 21981922
  3. The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression. Larochelle M, et al. Nucleic Acids Res, 2012 Nov 1. PMID 22965128, Free PMC Article
  4. Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Weick EM, et al. Cell, 2018 Jun 14. PMID 29906447, Free PMC Article
  5. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity EXP
Inferred from Experiment
more info
 PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in siRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRAMP complex EXP
Inferred from Experiment
more info
 PubMed 
part_of TRAMP complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TRAMP complex ATP-dependent RNA helicase subunit Mtr4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1344924..1348614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356009.1 → NP_001342839.1  TRAMP complex ATP-dependent RNA helicase subunit Mtr4 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14232, Q9USD3
    Conserved Domains (1) summary
    COG4581
    Location:52 → 1117
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
Nucleotide Protein
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