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gef3 RhoGEF for Cdc42/Rho3/Rho4 (Gef3) [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540334, updated on 18-Sep-2024

Summary

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Official Symbol
gef3
Official Full Name
RhoGEF for Cdc42/Rho3/Rho4 (Gef3)
Primary source
PomBase:SPBC29A3.17
Locus tag
SPOM_SPBC29A3.17
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (2070171..2072679)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein Rrs1 Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome c1 Cyt1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis. Wang N, et al. Mol Biol Cell, 2015 Jan 15. PMID 25411334, Free PMC Article
  2. The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast. Muñoz S, et al. J Biol Chem, 2014 Aug 8. PMID 24947517, Free PMC Article
  3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
  4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Rho guanine nucleotide exchange factors Gef3 interacts with the septin complex and activates Rho4 GTPase for septation during cytokinesis.
    Title: The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
  2. Gef3p contains a putative DH homology domain and a BAR/IMD-like domain. The protein localized to the division site late in mitosis, where it formed a ring that did not constrict with actomyosin ring.
    Title: The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of septum digestion after cytokinesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of protein localization to cell division site involved in cell separation after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in medial cortex septin ring EXP
Inferred from Experiment
more info
 PubMed 
is_active_in medial cortex septin ring IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RhoGEF for Cdc42/Rho3/Rho4 (Gef3)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2070171..2072679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021749.3 → NP_595845.1  RhoGEF for Cdc42/Rho3/Rho4 (Gef3) [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595845.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59679
    Conserved Domains (1) summary
    smart00325
    Location:76 → 267
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
Nucleotide Protein
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