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COX6AL Cytochrome c oxidase subunit 6A-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246451, updated on 18-Sep-2024

Summary

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Official Symbol
COX6ALprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 6A-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0050093
Locus tag
Dmel_CG30093
See related
AllianceGenome:FB:FBgn0050093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30093; COXD; COXE; Dmel\CG30093; NEST:bs02a12
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and cytochrome-c oxidase deficiency disease. Orthologous to human COX6A1 (cytochrome c oxidase subunit 6A1) and COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
52D3-52D4; 2-76 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15944028..15944567)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11831533..11832072)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bunker gear Neighboring gene Myelodysplasia/myeloid leukemia factor Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4aa1 Neighboring gene mir-4919 stem loop Neighboring gene Stretchin-Mlck Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sexually Antagonistic Mitonuclear Coevolution in Duplicate Oxidative Phosphorylation Genes. Havird JC, et al. Integr Comp Biol, 2019 Oct 1. PMID 30942855
  2. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817
  3. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article
  4. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article
  5. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models. Bussmann J, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28213160

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6A-like
Names
CG30093-PA
COX6AL-PA
cytochrome c oxidase polypeptide VIA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15944028..15944567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166124.4 → NP_725504.1  cytochrome c oxidase subunit 6A-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QPY7
    Related
    FBpp0086341
    Conserved Domains (1) summary
    cd00925
    Location:14 → 87
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QPY7 Q4QPY7

Gene LinkOut

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