U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp382 zinc finger protein 382 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246264, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp382provided by RGD
Official Full Name
zinc finger protein 382provided by RGD
Primary source
RGD:708385
See related
Ensembl:ENSRNOG00000020777 AllianceGenome:RGD:708385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ks1; Znf382
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human ZNF382 (zinc finger protein 382). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 49.9), Lung (RPKM 24.7) and 9 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfp382 in Genome Data Viewer
Location:
1q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94504344..94528316)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85377614..85400832)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88582641..88603219)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA5 Neighboring gene zinc finger protein 566 Neighboring gene zinc finger protein 260 Neighboring gene zinc finger protein 146 Neighboring gene prothymosin alpha, pseudogene 5 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene ribosomal protein S24, pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. Gebelein B, et al. J Clin Invest, 1998 Dec 1. PMID 9835615, Free PMC Article
  2. Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. Gebelein B, et al. Mol Cell Biol, 2001 Feb. PMID 11154279, Free PMC Article
  3. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Liu Z, et al. Clin Cancer Res, 2014 Sep 1. PMID 25009298, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC156588

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 382
Names
KRAB/zinc finger suppressor protein 1 (KS1)
multiple zinc finger and krueppel-associated box protein KS1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393683.1 → NP_001380612.1  zinc finger protein 382 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000069192.2, ENSRNOT00000087931.2
    Conserved Domains (3) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:293 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001393684.1 → NP_001380613.1  zinc finger protein 382 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    A0JPL0, Q62977
    Conserved Domains (3) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:293 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_144749.2 → NP_653350.1  zinc finger protein 382 isoform 2

    See identical proteins and their annotated locations for NP_653350.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JSS4
    Related
    ENSRNOP00000028187.4, ENSRNOT00000028187.7
    Conserved Domains (6) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:293 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:493 → 513
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:505 → 530
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94504344..94528316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280994.1 → XP_063137064.1  zinc finger protein 382 isoform X6

  2. XM_063281003.1 → XP_063137073.1  zinc finger protein 382 isoform X8

    UniProtKB/TrEMBL
    A0A8L2UPH4

  3. XM_063280982.1 → XP_063137052.1  zinc finger protein 382 isoform X3

  4. XM_063280998.1 → XP_063137068.1  zinc finger protein 382 isoform X7

  5. XM_063280978.1 → XP_063137048.1  zinc finger protein 382 isoform X2

  6. XM_063280991.1 → XP_063137061.1  zinc finger protein 382 isoform X5

  7. XM_063280977.1 → XP_063137047.1  zinc finger protein 382 isoform X1

  8. XM_063280989.1 → XP_063137059.1  zinc finger protein 382 isoform X4

  9. XM_063280996.1 → XP_063137066.1  zinc finger protein 382 isoform X6

RNA

  1. XR_010063130.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JPL0.1 GenPept UniProtKB/Swiss-Prot:A0JPL0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous