Pilra paired immunoglobin-like type 2 receptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pilraprovided by MGI
Official Full Name: paired immunoglobin-like type 2 receptor alphaprovided by MGI
Primary source: MGI:MGI:2450529
See related: Ensembl:ENSMUSG00000046245 AllianceGenome:MGI:2450529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FDF03
Summary: Predicted to enable MHC class I protein binding activity. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in heart ventricle; lung; and urethra. Orthologous to several human genes including PILRA (paired immunoglobin like type 2 receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 6.1), bladder adult (RPKM 3.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.77 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137820214..137834540, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137821952..137836278, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CD8alpha-PILRalpha interaction maintains CD8(+) T cell quiescence.
Title: The CD8α-PILRα interaction maintains CD8(+) T cell quiescence.
Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle.
Title: Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.
Data suggest that immune inhibitory receptor, PILRalpha, plays an important role in the prevention of obesity and liver fibrosis.
Title: Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.
Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.
Title: Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
negatively regulates inflammatory colitis by reducing the neutrophil and macrophage infiltration
Title: Negative regulation of DSS-induced experimental colitis by PILRα.
demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation
Title: Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages.
Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.
Title: PILRα negatively regulates mouse inflammatory arthritis.
regulates neutrophil recruitment in inflammatory responses modulation of integrin activation
Title: Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.
Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).
Title: Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands.
These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
Title: PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

AV021745 (e-PCR)
- UniSTS:165435

NoName (e-PCR)
- UniSTS:493202

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paired immunoglobulin-like type 2 receptor alpha

Names: cell surface receptor FDF03; inhibitory receptor PILR-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.