U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cyp2j13 cytochrome P450, family 2, subfamily j, polypeptide 13 [ Mus musculus (house mouse) ]

Gene ID: 230459, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Cyp2j13provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily j, polypeptide 13provided by MGI
Primary source
MGI:MGI:2385197
See related
Ensembl:ENSMUSG00000028571 AllianceGenome:MGI:2385197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 1.3) and kidney adult (RPKM 0.1) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 C5; 4 44.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95930897..95965803, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96042660..96077566, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene hook microtubule tethering protein 1 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene STARR-seq mESC enhancer starr_10818 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 12 Neighboring gene STARR-seq mESC enhancer starr_10819 Neighboring gene STARR-seq mESC enhancer starr_10820 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 11,12-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate 14,15-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables linoleic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytochrome P450, family 2, subfamily j, polypeptide 13
Names
cytochrome P450, 2j13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346539.1 → NP_001333468.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL772212, AL772395
    Consensus CDS
    CCDS84755.1
    UniProtKB/TrEMBL
    B1AWM5, Q91W71
    Related
    ENSMUSP00000095587.3, ENSMUST00000097973.3

  2. NM_001346540.1 → NP_001333469.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL772212, AL772395
    Consensus CDS
    CCDS89780.1
    UniProtKB/TrEMBL
    B1AWM4, Q91W71
    Related
    ENSMUSP00000102693.3, ENSMUST00000107078.9

  3. NM_145548.4 → NP_663523.2  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 1

    See identical proteins and their annotated locations for NP_663523.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript and encodes the longest isoform.
    Source sequence(s)
    AL772212, AL772395
    Consensus CDS
    CCDS18368.1
    UniProtKB/TrEMBL
    Q3UNV4
    Related
    ENSMUSP00000030305.7, ENSMUST00000030305.13
    Conserved Domains (1) summary
    pfam00067
    Location:44 → 475
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    95930897..95965803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502935.3 → XP_006502998.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:44 → 447
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools