Sprr2g small proline-rich protein 2G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr2gprovided by MGI
Official Full Name: small proline-rich protein 2Gprovided by MGI
Primary source: MGI:MGI:1330348
See related: Ensembl:ENSMUSG00000046203 AllianceGenome:MGI:1330348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene is a member of a tandemly arrayed set of genes that encode small proline-rich proteins, which are involved in epidermal barrier formation and are upregulated under stress conditions. While expression of this gene has been demonstrated, a reference genome insertion would disrupt its open reading frame, and it is thus classified as a transcribed pseudogene. However, transcripts without this insertion have also been described, and these would potentially encode a small proline-rich protein. [provided by RefSeq, Jul 2008]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Biased expression in subcutaneous fat pad adult (RPKM 5.6) and ovary adult (RPKM 1.6) See more
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92281222..92282536)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92373915..92375229)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epidermis development	NAS Non-traceable Author Statement more info	PubMed
involved_in keratinocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small proline-rich protein 2G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.