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gcy-9 Receptor-type guanylate cyclase gcy-9 [ Caenorhabditis elegans ]

Gene ID: 191645, updated on 18-Sep-2024

Summary

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Official Symbol
gcy-9
Official Full Name
Receptor-type guanylate cyclase gcy-9
Primary source
WormBase:WBGene00001536
Locus tag
CELE_ZK455.2
See related
AllianceGenome:WB:WBGene00001536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including cellular response to acidic pH; detection of carbon dioxide; and positive regulation of neuronal action potential. Located in neuronal cell body and non-motile cilium. Is expressed in BAGL and BAGR. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
24
Sequence:
Chromosome: X; NC_003284.9 (11332110..11337883, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sphingomyelin phosphodiesterase 2 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Galanin-like G-protein coupled receptor npr-9 Neighboring gene ncRNA Neighboring gene Cytoplasmic aconitate hydratase Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer. Martínez-Velázquez LA, et al. Proc Natl Acad Sci U S A, 2018 Jan 16. PMID 29282322, Free PMC Article
  2. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Hallem EA, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173231, Free PMC Article
  3. A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. Brandt JP, et al. PLoS One, 2012. PMID 22479504, Free PMC Article
  4. A chemoreceptor that detects molecular carbon dioxide. Smith ES, et al. J Biol Chem, 2013 Dec 27. PMID 24240097, Free PMC Article
  5. Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans. Rojo Romanos T, et al. Sci Rep, 2017 Jan 31. PMID 28139692, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. One component of the BAG transduction pathway, the receptor-type guanylate cyclase GCY-9, suffices to confer cellular sensitivity to both molecular CO2 and acid, indicating that it is a bifunctional chemoreceptor.
    Title: A chemoreceptor that detects molecular carbon dioxide.
  2. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons
    Title: A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.
  3. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
    Title: Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuronal action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Receptor-type guanylate cyclase gcy-9
NP_509897.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11332110..11337883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077496.6 → NP_509897.3  Receptor-type guanylate cyclase gcy-9 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E7EAU8, Q23496
    Conserved Domains (6) summary
    smart00044
    Location:862 → 1054
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:889 → 1076
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:69 → 404
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:837 → 883
    HNOBA; Heme NO binding associated
    cl10011
    Location:66 → 416
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21453
    Location:550 → 820
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7EAU8.1

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