U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rab-28 Ras-related protein Rab-28 [ Caenorhabditis elegans ]

Gene ID: 189429, updated on 12-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
rab-28
Gene description
Ras-related protein Rab-28
Locus tag
CELE_Y11D7A.4
See related
AllianceGenome:WB:WBGene00004281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Involved in several processes, including axoneme assembly; locomotory exploration behavior; and regulation of cilium assembly. Located in several cellular components, including ciliary base; ciliary transition zone; and periciliary membrane compartment. Is expressed in neurons and in male. Used to study ciliopathy. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rab-28 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (9242074..9244012, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene UNC93-like protein MFSD11 Neighboring gene DUF148 domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Akella JS, et al. Elife, 2020 Feb 26. PMID 32101165, Free PMC Article
  2. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. Jensen VL, et al. PLoS Genet, 2016 Dec. PMID 27930654, Free PMC Article
  3. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Kaletsky R, et al. Nature, 2016 Jan 7. PMID 26675724, Free PMC Article
  4. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
  5. Small GTPases. Lundquist EA. WormBook, 2006 Jan 17. PMID 18050472, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding.
    Title: Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding.
  2. our findings present a new approach for identifying ciliary proteins, and unveil RAB28, a GTPase most closely related to the BBS protein RABL4/IFT27, as an IFT-associated cargo with BBSome-dependent cell autonomous and non-autonomous functions at the ciliary base.
    Title: Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amphid sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ras-related protein Rab-28
NP_501609.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9242074..9244012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069208.3 → NP_501609.1  Ras-related protein Rab-28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501609.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    I7EVL1, Q9XWR6
    Conserved Domains (1) summary
    cd04109
    Location:36 → 248
    Rab28; Rab GTPase family 28 (Rab28)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XWR6.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools