U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

serr-1 L-serine ammonia-lyase [ Caenorhabditis elegans ]

Gene ID: 187970, updated on 19-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
serr-1
Gene description
L-serine ammonia-lyase
Locus tag
CELE_T01H8.2
See related
AllianceGenome:WB:WBGene00011353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including L-serine ammonia-lyase activity; amino-acid racemase activity; and anion binding activity. Predicted to be involved in D-serine biosynthetic process; L-serine metabolic process; and pyruvate biosynthetic process. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See serr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (8571556..8573749, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene LSDAT_euk domain-containing protein;Transient receptor potential channel Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase Neighboring gene Smad protein daf-8

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a homologue of mammalian serine racemase from Caenorhabditis elegans: the enzyme is not critical for the metabolism of serine in vivo. Katane M, et al. Genes Cells, 2016 Sep. PMID 27458110
  2. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. Saitoh Y, et al. J Neurosci, 2020 Sep 23. PMID 32855271, Free PMC Article
  3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in D-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organonitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
L-serine ammonia-lyase
NP_492318.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8571556..8573749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059917.3 → NP_492318.1  L-serine ammonia-lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492318.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93968
    Conserved Domains (1) summary
    cd01562
    Location:7 → 311
    Thr-dehyd; Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous