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M18.6 CULT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187461, updated on 23-Nov-2023

Summary

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Gene symbol
M18.6
Gene description
CULT domain-containing protein
Primary source
WormBase:WBGene00010891
Locus tag
CELE_M18.6
See related
AllianceGenome:WB:WBGene00010891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein ubiquitination. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (12121310..12122882)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA damage-binding protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein Neighboring gene Palmitoyltransferase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CULT domain-containing protein
NP_001293924.1
  • Confirmed by transcript evidence
NP_502300.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12121310..12122882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306995.3 → NP_001293924.1  CULT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACL6
    Conserved Domains (3) summary
    smart00464
    Location:35 → 102
    LON; Found in ATP-dependent protease La (LON)
    cd15777
    Location:241 → 336
    CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
    cl19481
    Location:132 → 234
    LON; Found in ATP-dependent protease La (LON)

  2. NM_069899.4 → NP_502300.2  CULT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502300.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21558
    Conserved Domains (2) summary
    smart00464
    Location:60 → 138
    LON; Found in ATP-dependent protease La (LON)
    cd15777
    Location:277 → 372
    CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
Nucleotide Protein
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