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tctn-1 Tectonic domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 184035, updated on 18-Sep-2024

Summary

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Official Symbol
tctn-1
Official Full Name
Tectonic domain-containing protein
Primary source
WormBase:WBGene00017120
Locus tag
CELE_E04A4.6
See related
AllianceGenome:WB:WBGene00017120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in cilium assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in ciliary transition zone. Is expressed in amphid neurons and phasmid neurons. Human ortholog(s) of this gene implicated in Joubert syndrome 13; Joubert syndrome 18; and orofaciodigital syndrome IV. Orthologous to several human genes including TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (4745823..4747832, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z Neighboring gene putative mitochondrial import inner membrane translocase subunit tim-17B.1 Neighboring gene Cytochrome c 2.1 Neighboring gene Large ribosomal subunit protein eL20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. Yee LE, et al. PLoS Genet, 2015 Nov. PMID 26540106, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tectonic domain-containing protein
NP_500628.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4745823..4747832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068227.4 → NP_500628.2  Tectonic domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500628.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44478
Nucleotide Protein
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