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twk-39 Potassium channel domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182864, updated on 11-Apr-2024

Summary

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Gene symbol
twk-39
Gene description
Potassium channel domain-containing protein
Primary source
WormBase:WBGene00006690
Locus tag
CELE_C24H11.8
See related
AllianceGenome:WB:WBGene00006690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in migraine with aura. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (11795748..11803243)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BTB domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. Buckingham SD, et al. Trends Pharmacol Sci, 2005 Jul. PMID 15939489
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Potassium channel domain-containing protein
NP_001076638.1
  • Partially confirmed by transcript evidence
NP_001076639.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11795748..11803243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083169.2 → NP_001076638.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076638.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVD1
    Conserved Domains (1) summary
    pfam07885
    Location:120 → 177
    Ion_trans_2; Ion channel

  2. NM_001083170.3 → NP_001076639.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076639.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1EHR5
    Conserved Domains (1) summary
    pfam07885
    Location:120 → 177
    Ion_trans_2; Ion channel
Nucleotide Protein
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