got-1.2 Aspartate aminotransferase, cytoplasmic [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: got-1.2
Gene description: Aspartate aminotransferase, cytoplasmic
Locus tag: CELE_T01C8.5
See related: AllianceGenome:WB:WBGene00020146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity. Involved in positive regulation of glutamate metabolic process. Located in cytoplasm. Is expressed in several structures, including egg-laying apparatus; excretory cell; hypodermis; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to several human genes including GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See got-1.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (16791347..16793126, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01C8.5 (e-PCR)
- UniSTS:310595

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glutamate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aspartate aminotransferase, cytoplasmic

NP_510709.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16791347..16793126 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078308.8 → NP_510709.1 Aspartate aminotransferase, cytoplasmic [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510709.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22067

Conserved Domains (2) summary

pfam00155
Location:28 → 397

Aminotran_1_2; Aminotransferase class I and II

cl18945
Location:1 → 404

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...