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prx-1 AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1 [ Caenorhabditis elegans ]

Gene ID: 181538, updated on 25-Apr-2024

Summary

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Gene symbol
prx-1
Gene description
AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1
Primary source
WormBase:WBGene00004191
Locus tag
CELE_C11H1.4
See related
AllianceGenome:WB:WBGene00004191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to be located in peroxisome. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 1; infantile Refsum disease; and peroxisome biogenesis disorder 1A. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See prx-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
24
Sequence:
Chromosome: X; NC_003284.9 (14313927..14326726)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Golgi pH regulator Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA Neighboring gene DUF3456 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. Isermann K, et al. J Mol Biol, 2004 May 7. PMID 15099742
  2. RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Petriv OI, et al. Physiol Genomics, 2002 Aug 14. PMID 12181365
  3. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
  4. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
  5. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Simmer F, et al. PLoS Biol, 2003 Oct. PMID 14551910, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1
NP_001367171.1
  • Confirmed by transcript evidence
NP_510386.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14313927..14326726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077985.7 → NP_510386.2  Peroxisomal ATPase PEX1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510386.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED99
    Conserved Domains (3) summary
    COG0464
    Location:511 → 938
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09262
    Location:103 → 179
    PEX-1N; Peroxisome biogenesis factor 1, N-terminal
    cl38936
    Location:481 → 522
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001381145.1 → NP_001367171.1  AAA+ ATPase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A6ZJ67
    Conserved Domains (2) summary
    pfam17862
    Location:191 → 227
    AAA_lid_3; AAA+ lid domain
    cl38936
    Location:10 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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