utx-1 JmjC domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: utx-1
Gene description: JmjC domain-containing protein
Primary source: WormBase:WBGene00017046
Locus tag: CELE_D2021.1
See related: AllianceGenome:WB:WBGene00017046
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in cell fate specification; histone H3-K27 demethylation; and programmed cell death. Part of MLL3/4 complex. Is expressed in several structures, including germ line; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to several human genes including KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See utx-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 14

Sequence:: Chromosome: X; NC_003284.9 (8557146..8563238)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
Title: H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
These results demonstrate that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression across generations and during development.
Title: Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.
these results demonstrate that UTX-1 is required for many aspects of nematode development; but, unexpectedly, this function is independent of its enzymatic activity
Title: The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
progressive increases in gene expression and loss of H3K27me3 on insulin/IGF-1 signaling components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging.
Title: Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2021.1 (e-PCR)
- UniSTS:312232

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27me2/H3K27me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MLL3/4 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: JmjC domain-containing protein

NP_001309685.1

Confirmed by transcript evidence

NP_001309686.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8557146..8563238

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322627.4 → NP_001309686.1 JmjC domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MCP7

Conserved Domains (6) summary

smart00028
Location:385 → 414

TPR; Tetratricopeptide repeats

pfam02373
Location:874 → 982

JmjC; JmjC domain, hydroxylase

smart00558
Location:840 → 904

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00006
Location:315 → 343

TPR; TPR repeat [structural motif]

pfam00515
Location:349 → 382

TPR_1; Tetratricopeptide repeat

pfam13414
Location:348 → 414

TPR_11; TPR repeat
NM_001322626.4 → NP_001309685.1 JmjC domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBT2

Conserved Domains (6) summary

smart00028
Location:390 → 419

TPR; Tetratricopeptide repeats

pfam02373
Location:879 → 987

JmjC; JmjC domain, hydroxylase

smart00558
Location:845 → 909

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

sd00006
Location:315 → 348

TPR; TPR repeat [structural motif]

pfam00515
Location:354 → 387

TPR_1; Tetratricopeptide repeat

pfam13414
Location:353 → 419

TPR_11; TPR repeat