ddr-1 Discoidin domain-containing receptor A [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ddr-1
Official Full Name: Discoidin domain-containing receptor A
Primary source: WormBase:WBGene00016104
Locus tag: CELE_C25F6.4
See related: AllianceGenome:WB:WBGene00016104
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in motor neuron axon guidance and positive regulation of axon regeneration. Predicted to be located in axon; perikaryon; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in hypodermis; intestinal muscle; nervous system; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung non-small cell carcinoma; osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1) and DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Discoidin domain receptors guide axons along longitudinal tracts in C. elegans
Title: Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_508926.2

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The following sections contain reference sequences that belong to a specific genome build. Explain