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clh-4 Chloride channel protein [ Caenorhabditis elegans ]

Gene ID: 180687, updated on 25-Apr-2024

Summary

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Gene symbol
clh-4
Gene description
Chloride channel protein
Primary source
WormBase:WBGene00000531
Locus tag
CELE_T06F4.2
See related
AllianceGenome:WB:WBGene00000531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See clh-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (4094867..4100573, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Yin X, et al. Am J Physiol Cell Physiol, 2007 Jan. PMID 16899547
  2. Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. Bianchi L, et al. Neurosci Lett, 2001 Feb 23. PMID 11165764
  3. Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression. Nehrke K, et al. Am J Physiol Cell Physiol, 2000 Dec. PMID 11078724
  4. CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease. Jentsch TJ, et al. Physiol Rev, 2018 Jul 1. PMID 29845874
  5. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Armstrong KR, et al. Mol Genet Genomics, 2010 Jan. PMID 19921263

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables voltage-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chloride channel protein
NP_001024885.1
  • Confirmed by transcript evidence
NP_001024886.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4094867..4100573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029715.3 → NP_001024886.1  Chloride channel protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0J1, Q9BMK8
    Conserved Domains (3) summary
    cd03683
    Location:141 → 618
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:888 → 945
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:202 → 596
    Voltage_CLC; Voltage gated chloride channel

  2. NM_001029714.2 → NP_001024885.1  Chloride channel protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZP4, Q9BMK8
    Conserved Domains (3) summary
    cd03683
    Location:141 → 618
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:885 → 942
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:202 → 596
    Voltage_CLC; Voltage gated chloride channel
Nucleotide Protein
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