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aagr-4 Glycoside hydrolase family 31 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180400, updated on 18-Sep-2024

Summary

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Official Symbol
aagr-4
Official Full Name
Glycoside hydrolase family 31 N-terminal domain-containing protein
Primary source
WormBase:WBGene00018682
Locus tag
CELE_F52D1.1
See related
AllianceGenome:WB:WBGene00018682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (460651..466899)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Gag-pol polyprotein Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene Protein quiver Neighboring gene WD_REPEATS_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
  2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycoside hydrolase family 31 N-terminal domain-containing protein
NP_508105.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    460651..466899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075704.7 → NP_508105.2  Glycoside hydrolase family 31 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508105.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17352
    Conserved Domains (4) summary
    cd06603
    Location:336 → 804
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:197 → 336
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam16338
    Location:61 → 146
    DUF4968; Domain of unknown function (DUF4968)
    pfam17137
    Location:779 → 852
    DUF5110; Domain of unknown function (DUF5110)
Nucleotide Protein
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