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ubc-19 UBC core domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180223, updated on 18-Sep-2024

Summary

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Official Symbol
ubc-19
Official Full Name
UBC core domain-containing protein
Primary source
WormBase:WBGene00006714
Locus tag
CELE_Y69H2.6
See related
AllianceGenome:WB:WBGene00006714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus and protein polyubiquitination. Predicted to be active in nucleus. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (18686321..18689762, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TIL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CUB domain-containing protein Neighboring gene ncRNA Neighboring gene ATP-dependent DNA helicase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
  2. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
  3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
  4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBC core domain-containing protein
NP_507647.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    18686321..18689762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075246.8 → NP_507647.1  UBC core domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507647.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1U4
    Conserved Domains (1) summary
    cd00195
    Location:21 → 167
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
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