nxf-2 Nuclear RNA export factor 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nxf-2
Official Full Name: Nuclear RNA export factor 2
Primary source: WormBase:WBGene00003835
Locus tag: CELE_C15H11.6
See related: AllianceGenome:WB:WBGene00003835
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nxf-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (14416067..14417835, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
Title: The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15H11.5 (e-PCR)
- UniSTS:309086

C15H11.6 (e-PCR)
- UniSTS:309087

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear RNA export factor 2

NP_506568.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14416067..14417835 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074167.8 → NP_506568.2 Nuclear RNA export factor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506568.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XVS8

Conserved Domains (2) summary

sd00035
Location:55 → 97

LRR_NTF; leucine-rich repeat [structural motif]

cd21340
Location:96 → 159

PPP1R42; protein phosphatase 1 regulatory subunit 42