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pfk-1.2 ATP-dependent 6-phosphofructokinase 2 [ Caenorhabditis elegans ]

Gene ID: 179335, updated on 18-Sep-2024

Summary

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Official Symbol
pfk-1.2
Official Full Name
ATP-dependent 6-phosphofructokinase 2
Primary source
WormBase:WBGene00008230
Locus tag
CELE_C50F4.2
See related
AllianceGenome:WB:WBGene00008230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See pfk-1.2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (9531801..9534537)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CHK kinase-like domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Cysteine proteinase Neighboring gene COMM domain-containing protein Neighboring gene Transcription termination factor 3, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex differences in carbohydrate metabolism are linked to gene expression in Caenorhabditis elegans. Miersch C, et al. PLoS One, 2012. PMID 22984551, Free PMC Article
  2. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  3. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  4. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328
  5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphofructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent 6-phosphofructokinase 2
NP_505457.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9531801..9534537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073056.4 → NP_505457.1  ATP-dependent 6-phosphofructokinase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27483
    Conserved Domains (2) summary
    TIGR02478
    Location:11 → 750
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
    cl00204
    Location:8 → 747
    PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27483.1

Gene LinkOut

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