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natc-2 N-acetyltransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178916, updated on 18-Sep-2024

Summary

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Official Symbol
natc-2
Official Full Name
N-acetyltransferase domain-containing protein
Primary source
WormBase:WBGene00015074
Locus tag
CELE_B0238.10
See related
AllianceGenome:WB:WBGene00015074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptide alpha-N-acetyltransferase activity. Involved in dauer larval development. Predicted to be part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (5274076..5275615)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TIL domain-containing protein Neighboring gene HMG box domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Calx-beta domain-containing protein;Sodium/calcium exchanger membrane region domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Daily variation in melatonin synthesis and arylalkylamine N-acetyltransferase activity in the nematode Caenorhabditis elegans. Migliori ML, et al. J Pineal Res, 2012 Aug. PMID 21995323
  2. The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. Warnhoff K, et al. PLoS Genet, 2014 Oct. PMID 25330323, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
N-acetyltransferase domain-containing protein
NP_504411.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5274076..5275615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072010.8 → NP_504411.1  N-acetyltransferase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16486
    Conserved Domains (1) summary
    COG0456
    Location:94 → 243
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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