srgp-1 Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: srgp-1
Gene description: Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00006406
Locus tag: CELE_F12F6.5
See related: AllianceGenome:WB:WBGene00006406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activator activity; protein self-association; and small GTPase binding activity. Involved in several processes, including negative regulation of phagocytosis, engulfment; positive regulation of GTPase activity; and regulation of cell-cell adhesion. Located in adherens junction and cell cortex. Is expressed in hypodermis; nervous system; pharynx; somatic cell; and spermatheca. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Orthologous to several human genes including ARHGAP4 (Rho GTPase activating protein 4) and SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See srgp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11570500..11578699)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that loss of srgp-1 function promotes not only the clearance of already dead cells, but also the removal of cells that have been brought to the verge of death through sublethal apoptotic, necrotic or cytotoxic insults.
Title: Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.
Data establish a role for the F-BAR domain of SRGP-1 in promoting rapid and robust cell adhesion during embryonic closure events, independent of the Rho guanosine triphosphatase-activating protein domain.
Title: The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F12F6.5 (e-PCR)
- UniSTS:307466

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phagocytosis, engulfment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell-cell adhesion involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cellular anatomical entity	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho-GAP domain-containing protein

NP_001255566.1

Confirmed by transcript evidence

NP_001255567.1

Confirmed by transcript evidence

NP_001255568.1

Confirmed by transcript evidence

NP_001293964.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11570500..11578699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268637.2 → NP_001255566.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255566.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19370

Conserved Domains (2) summary

cd07656
Location:60 → 300

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:523 → 710

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001307035.3 → NP_001293964.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293964.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACU6

Conserved Domains (2) summary

cd07656
Location:24 → 264

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:487 → 674

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001268638.3 → NP_001255567.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255567.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT53

Conserved Domains (2) summary

cd07656
Location:1 → 239

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:462 → 649

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001268639.3 → NP_001255568.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255568.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT54

Conserved Domains (1) summary

cl02570
Location:75 → 262

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...