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adk-1 Adenosine kinase [ Caenorhabditis elegans ]

Gene ID: 178028, updated on 5-May-2024

Summary

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Gene symbol
adk-1
Gene description
Adenosine kinase
Primary source
WormBase:WBGene00011128
Locus tag
CELE_R07H5.8
See related
AllianceGenome:WB:WBGene00011128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable adenosine kinase activity. Predicted to be involved in AMP salvage; phosphorylation; and purine ribonucleoside salvage. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See adk-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11209309..11210831, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene NPH3 domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans. Kawasaki I, et al. Mol Cells, 2013 Nov. PMID 24218109, Free PMC Article
  2. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Adenosine kinase
NP_502104.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11209309..11210831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069703.10 → NP_502104.1  Adenosine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502104.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93934
    Conserved Domains (1) summary
    cl00192
    Location:12 → 341
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
Nucleotide Protein
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